Now that you’ve got a basic framework for your wireframes, you’re ready to dive in! You should have a fat stack of paper wireframes to work from, so the hard thinking should be done already.

This is the part of the process where you can relax a bit and switch your brain to “zen-like robot mode”. You don’t need to worry about making them beautiful; this is a rare moment when you can just use Helvetica and call it a day. Savor it.

Disclaimer: This is my current wireframing process for desktop-only sites. We, and everybody else, are still figuring the best scalable approach for responsive wireframing, although I believe that OmniGraffle can easily serve that purpose as well.