Recently I started to notice I very high number of LRU Nuked Objects on my websites, which was essentially wipping the entire Varnish Cache. I run Varnish with 4GB File cache and site ocntent is mostly served by external "Poor Man CDN".
I have several websites installed in subdirectories on my Mac laptop at /Users/davidnorman/Sites where I pointed the OS-included installation of Apache to use as my DocumentRoot.
Our problem was relatively simple. Have two languages (in our case English and French, English being the default) and show all content on a site regardless of the language chosen.